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Grating visual acuity results in the early treatment for retinopathy of prematurity study

, Velma Dobson, Graham E Quinn

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |July 13, 2011
    PubMed

    Insights

    Early treatment for retinopathy of prematurity (ROP) benefits type 1 cases, improving visual acuity. However, early treatment for type 2 ROP does not show a significant visual acuity advantage.

    Area of Science:

    • Ophthalmology
    • Neonatal Medicine
    • Pediatric Vision

    Background:

    • Retinopathy of prematurity (ROP) is a leading cause of childhood blindness.
    • High-risk prethreshold ROP requires careful management to optimize visual outcomes.
    • Early intervention strategies are being evaluated to prevent vision loss in premature infants.

    Purpose of the Study:

    • To compare grating visual acuity at age 6 in infants treated early (ET) versus those managed conventionally (CM) for high-risk prethreshold ROP.
    • To determine if early treatment for different types of prethreshold ROP impacts long-term visual acuity.

    Main Methods:

    • Randomized clinical trial involving infants with bilateral high-risk prethreshold ROP.
    • One eye received early treatment (ET), the other conventional management (CM), with crossover if ROP progressed.
    • Grating visual acuity was assessed at 6 years of age using Teller acuity cards by masked testers.

    Main Results:

    • No overall statistically significant difference in grating acuity between ET and CM for all high-risk prethreshold ROP.
    • Early treatment (ET) significantly improved grating acuity outcomes in type 1 ROP eyes compared to CM.
    • No significant visual acuity benefit was observed with ET in type 2 ROP eyes compared to CM.

    Conclusions:

    • Early treatment is beneficial for type 1 retinopathy of prematurity, improving grating visual acuity outcomes.
    • Conventional management with cautious monitoring for progression is recommended for type 2 ROP, as early treatment did not improve acuity.
    • These findings support tailored treatment strategies for ROP based on disease type to preserve vision.
    Abstract

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