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Related Concept Videos

Prosopagnosia01:24

Prosopagnosia

685
Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...
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Visual Agnosia01:12

Visual Agnosia

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Visual agnosia is a condition characterized by the inability to recognize visually presented objects despite having normal vision. For instance, a person with visual agnosia can describe the shape and color of an object but cannot identify or name it. This impairment does not affect their visual field, acuity, color vision, brightness discrimination, language, or memory. An example of this condition in a social setting is someone at a dinner party asking for "that silver thing with a round...
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Related Experiment Video

Updated: Jan 13, 2026

Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss
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Published on: April 11, 2025

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Evidence That Cerebral Visual Impairment May Evolve after Initial Brain Injury.

William V Good1, Ronald J Wong2, Chuan Hou1

  • 1The Smith-Kettlewell Eye Research Institute, San Francisco, California.

Ophthalmology
|January 9, 2026
PubMed
Summary
This summary is machine-generated.

An infant's initial brain injury can trigger a cascade of damage. This central nervous system (CNS) event leads to later-developing injuries in the extrastriate cortex during childhood.

Keywords:
acute bilirubin encephalopathyextrastriate cortexhyperbilirubinemiasVEPvisual cortex

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Pediatric Neurology

Background:

  • The developing brain is vulnerable to initial insults.
  • Central nervous system (CNS) injuries in infancy can have long-term consequences.
  • The extrastriate cortex plays a role in visual processing and development.

Purpose of the Study:

  • To investigate the link between early CNS insults and later extrastriate cortex damage.
  • To understand the chain reaction of neurodevelopmental injury following an initial brain insult.
  • To identify potential mechanisms leading to visual pathway abnormalities in childhood.

Main Methods:

  • Utilizing neuroimaging techniques to assess brain structure and function in infants with a history of CNS insults.
  • Longitudinal follow-up of children to monitor for the manifestation of extrastriate cortex injuries.
  • Analyzing developmental trajectories of visual processing in affected children.

Main Results:

  • Confirmed a correlation between early CNS insults and subsequent alterations in the extrastriate cortex.
  • Identified a pattern of delayed injury manifestation in the extrastriate cortex.
  • Observed functional and structural changes in the extrastriate cortex impacting visual development.

Conclusions:

  • An initial CNS insult in infancy can initiate a cascade leading to secondary extrastriate cortex injury.
  • These secondary injuries may not be apparent immediately but manifest later in childhood.
  • Understanding this injury pathway is crucial for early intervention in affected children.