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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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π-Stacking between Casiopeinas® and DNA bases.

Rodrigo Galindo-Murillo1, Joseelyne Hernandez-Lima, Mayra González-Rendón

  • 1Instituto de Química, Universidad Nacional Autónoma de México, México DF 04510, México.

Physical Chemistry Chemical Physics : PCCP
|July 13, 2011
PubMed
Summary

Casiopeínas®, copper complexes with antineoplastic activity, interact with DNA. This interaction involves electron transfer from adenine bases to the Casiopeína® ligand through π-π stacking, clarifying their mechanism of action.

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