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Updated: May 31, 2026

Live Imaging of the Mitochondrial Glutathione Redox State in Primary Neurons using a Ratiometric Indicator
Published on: October 20, 2021
Neuronal guidance: a redox signal involving Mical
Barbara W Bernstein1, James R Bamburg
1Dept. of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870, USA. Barbara.Bernstein@ColoState.edu
Abstract:
Mical, a redox enzyme, binds the cytoplasmic domain of the semaphorin receptor plexin A and mediates semaphorin-signaled collapse of the actin cytoskeleton. Recent work now shows that Mical's ability to bind actin filaments and destabilize them in a NADPH-dependent manner is responsible for semaphorin 1a's effects.
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