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Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR

Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR

Published on: February 4, 2018

Lyme disease-associated glomerulonephritis.

Finnian R Mc Causland¹, Sophie Niedermaier, Vanesa Bijol

¹Renal Division, Brigham and Women’s Hospital, Boston, MA, USA. fmccausland@partners.org

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association

|July 14, 2011

Summary

This summary is machine-generated.

Lyme disease can cause kidney problems, specifically glomerulonephritis. Early antibiotic and steroid treatment effectively resolved symptoms in two reported cases.

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Methods for Rapid Transfer and Localization of Lyme Disease Pathogens Within the Tick Gut

Methods for Rapid Transfer and Localization of Lyme Disease Pathogens Within the Tick Gut

Published on: February 14, 2011

Area of Science:

Nephrology
Infectious Diseases

Background:

Lyme disease, a tick-borne illness, is primarily known for its dermatological, rheumatological, and neurological manifestations.
Immune-mediated glomerular diseases can lead to significant renal dysfunction.

Observation:

Two patients presented with symptoms suggestive of glomerulonephritis following tick bites and erythema migrans rash.
Case 1: A 57-year-old female developed rapidly progressive glomerulonephritis with immune complex-mediated, membranoproliferative lesions.
Case 2: A 40-year-old male with pre-existing microscopic hematuria developed focal proliferative IgA nephropathy.

Findings:

Both patients showed improvement with a combination of antibiotics and corticosteroids.
Biopsies confirmed distinct immune-mediated glomerular pathologies in each case.
Lyme disease triggered or exacerbated these kidney conditions.

Implications:

Acute Lyme disease should be considered in the differential diagnosis of new-onset glomerulonephritis, particularly in endemic areas.
This highlights a potential link between Borrelia burgdorferi infection and immune-mediated kidney disease.
Prompt diagnosis and treatment may prevent irreversible renal damage.