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Updated: May 31, 2026

High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds
Published on: January 23, 2018
RFX6 is needed for the development and maintenance of the β-cell phenotype
Nadine Taleb1, Constantin Polychronakos
1Departments of Pediatrics and Human Genetics, McGill University, Montreal, QC, Canada. constantin.polychronakos@mcgill.ca
Abstract:
RFX6 has recently been found to be essential for the development of the endocrine pancreas through studies in both humans and mice. Interestingly, this gene maintains a specific expression in the postnatal hormone producing cells of the pancreas. Moreover in humans, different types of diabetes mellitus affect obligate carriers of RFX6 mutations. Therefore, RFX6 appears to have a pivotal role in the maintenance of the phenotype of the β-cells in addition to their development. Extensive research is needed to specify this role and explore its significance in the efforts to treat diabetes with medications, or more importantly, through β-cell replacement.
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