Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long vs. short axial field-of-view PET scanners for brain imaging: a phantom study.

Frontiers in nuclear medicine·2026
Same author

Intravitreal faricimab pharmacokinetics assessed by PET imaging in a neovascular Age-related Macular Degeneration rat model.

International journal of pharmaceutics: X·2026
Same author

Total Body PET.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
Same author

The Role of Motion Correction Tools in Left Ventricular Functional Parameters Measured by Gated [<sup>13</sup>N]NH<sub>3</sub> PET/CT.

Diagnostics (Basel, Switzerland)·2026
Same author

PET rapid image reconstruction challenge (PETRIC).

Frontiers in nuclear medicine·2026
Same author

POU1F1 induces cancer stem cell-like traits in breast cancer cells by IL-6/JAK2/STAT3 activation and enrichment of ALDH.

NPJ breast cancer·2026

Related Experiment Video

Updated: May 31, 2026

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Comparative evaluation of scatter correction in 3D PET using different scatter-level approximations.

Irene Polycarpou1, Kris Thielemans, Ravindra Manjeshwar

  • 1Division of Imaging Sciences and Biomedical Engineering, The Rayne Institute, St. Thomas' Hospital, King's College London, London, SE1 7EH, UK.

Annals of Nuclear Medicine
|July 14, 2011
PubMed
Summary

Accurate scatter correction in 3D Positron Emission Tomography (PET) is crucial. This study shows that while double scatter correction improves accuracy, scaling single scatter data is a viable approximation, with STIR demonstrating good agreement with simulations.

More Related Videos

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images
08:02

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images

Published on: November 15, 2024

Related Experiment Videos

Last Updated: May 31, 2026

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images
08:02

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images

Published on: November 15, 2024

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Computational Physics

Background:

  • Photon scatter in 3D Positron Emission Tomography (PET) significantly degrades image quality and quantification accuracy.
  • Current scatter estimation methods often approximate multiple scattering by scaling single scatter simulations, but their accuracy for significant multiple scatter is unclear.
  • Evaluating the necessity and precision of multiple scatter correction is vital for reliable PET imaging.

Purpose of the Study:

  • To assess the importance and accuracy requirements for correcting multiple scattered photons in 3D PET.
  • To evaluate the performance of the analytic single scatter simulation (SSS) implementation within the open-source STIR library for scatter correction.
  • To compare different scatter order approximations and scaling methods against Monte Carlo simulations.

Main Methods:

  • Utilized Monte Carlo (SimSET) data for anthropomorphic phantom simulations.
  • Reconstructed images using iterative algorithms and compared 3D filtered back-projection reprojection.
  • Evaluated various scatter orders and scaling approaches, including tail-fit and total-fit methods.

Main Results:

  • Scatter correction significantly improved quantification accuracy, reducing Standard Uptake Value (SUV) in the heart from 4.0 to 3.0.
  • Both single and double scatter correction enhanced accuracy, with double scatter correction yielding ideal values.
  • Scaling single scatter data using tail-fit or total-fit provided reasonable approximations, achieving near-ideal SUV values.
  • STIR's SSS implementation with total-fit achieved an SUV of 3.0, matching ideal values.

Conclusions:

  • Correction for double scatter is essential for improving image contrast and accurately estimating activity distribution in PET.
  • Scaling single scatter distributions serves as a practical and effective approximation for compensating total scatter.
  • The scatter correction methodology implemented in STIR shows excellent agreement with established Monte Carlo simulation results.