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Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers01:12

Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers

Class III antiarrhythmic drugs are a group of medications that can prolong action potentials in the heart. They achieve this by blocking potassium channels or enhancing inward currents from sodium channels. However, these drugs have a unique property of "reverse use-dependence," which is most pronounced at slower heart rates and can lead to torsades de pointes—a specific type of arrhythmia. However, it is essential to note that excessive QT interval prolongation—a measure of the heart's...
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Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Dysrhythmias IV: Characteristics of Bradyarrhythmias01:18

Dysrhythmias IV: Characteristics of Bradyarrhythmias

Bradyarrhythmias are cardiac rhythm disorders characterized by a slower-than-normal heart rate, typically defined as fewer than 60 beats per minute. Some of which are discussed here:Sinus BradycardiaSinus bradycardia presents a heart rate lower than 60 beats per minute, with a regular rhythm originating from the SA node. The ECG typically shows normal P waves preceding each QRS complex, a normal PR interval (0.12 to 0.20 seconds), and a normal QRS duration (0.06 to 0.10 seconds).First-Degree AV...
Graves Disease II: Pathophysiology01:24

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Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
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Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...

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Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
04:09

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Published on: September 20, 2024

Reversible atrioventricular blocks in thyroid storm.

Sudhir Kumar Atri1, S N Chugh, Sandeep Goya

  • 1Dept. of Medicine and Biochemistry, Pt. BD Sharma PGIMS, Rohtak, Haryana.

The Journal of the Association of Physicians of India
|July 15, 2011
PubMed
Summary
This summary is machine-generated.

Thyroid storm can cause heart blocks, which usually require pacemakers. This case shows recovery from atrioventricular blocks solely with antithyroid treatment, highlighting a novel therapeutic approach.

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Area of Science:

  • Cardiology
  • Endocrinology
  • Thyroidology

Background:

  • Atrioventricular (AV) and sinoatrial (SA) blocks are uncommon in thyrotoxicosis.
  • Thyroid storm is a life-threatening emergency requiring prompt diagnosis and management.
  • AV blocks typically necessitate cardiac pacing.

Observation:

  • A patient presented with newly developed AV blocks during a state of thyrotoxicosis.
  • The patient did not undergo any cardiac pacing procedures.

Findings:

  • The patient's AV blocks resolved completely with the initiation of antithyroid treatment.
  • This suggests a direct link between thyroid hormone levels and cardiac conduction abnormalities.

Implications:

  • Antithyroid treatment may be a viable alternative to pacing in select cases of AV blocks associated with thyroid storm.
  • Further research is warranted to elucidate the mechanisms underlying thyroid-induced heart blocks.
  • This case highlights the importance of considering thyroid dysfunction in patients presenting with conduction abnormalities.