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Related Experiment Video

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The Efficacy and Underlying Pathway Mechanisms of ShiDuGao Treatment for Anus Eczema Based on GEO Datasets and Network Pharmacology

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Two new dammarane monodesmosides from Centella asiatica.

Xiao-Xiang Weng¹, Yan Shao, Yun-Yan Chen

¹Department of Chinese Traditional Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, China.

Journal of Asian Natural Products Research

|July 15, 2011

Summary

Researchers identified four new dammarane monodesmosides and ginsenosides from Centella asiatica. These compounds, along with eleven known ones, were isolated and tested for their in vitro cytotoxicity, expanding knowledge of this plant

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Last Updated: May 31, 2026

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Published on: January 12, 2024

Area of Science:

Phytochemistry
Natural Products Chemistry
Pharmacology

Background:

Centella asiatica is a medicinal plant with a rich history of traditional use.
The chemical constituents of Centella asiatica are complex and diverse, with ongoing research to identify novel compounds.
Dammarane monodesmosides and ginsenosides are classes of compounds known for their potential biological activities.

Purpose of the Study:

To isolate and characterize new dammarane monodesmosides and ginsenosides from Centella asiatica.
To identify known compounds from the genus Centella asiatica for the first time.
To evaluate the in vitro cytotoxicity of all isolated compounds.

Main Methods:

Isolation of compounds using chromatographic techniques.
Structure elucidation through comprehensive spectroscopic analyses (NMR, MS).
Chemical methods for structural confirmation.
In vitro cytotoxicity assays.

Main Results:

Two new dammarane monodesmosides, centellosides A (1) and B (2), were identified.
Two new natural products, ginsenosides Mc (10) and Y (11), were discovered.
Eleven known compounds (3-9 and 12-15) were isolated for the first time from this genus.
All isolated compounds were evaluated for their in vitro cytotoxic effects.

Conclusions:

The study successfully identified novel dammarane monodesmosides and ginsenosides from Centella asiatica.
The findings expand the known chemical diversity of Centella asiatica.
Further investigation into the cytotoxic properties of these compounds is warranted.