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Two new biflavonones from Coreopsis tinctoria.

Ren-Jie Yan1, Mo-Ying Li1, Hai-Feng Zhou1

  • 1a State Key Laboratory of New Drug & Pharmaceutical Process , Shanghai Institute of Pharmaceutical Industry , Shanghai 200040 , China.

Journal of Asian Natural Products Research
|April 5, 2017
PubMed
Summary

Two novel biflavonone compounds, sikokianin D and E, were identified in Coreopsis tinctoria. Their chemical structures were determined using advanced spectroscopic methods.

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Area of Science:

  • Natural Product Chemistry
  • Phytochemistry
  • Organic Chemistry

Background:

  • Coreopsis tinctoria is a plant species known for its potential medicinal properties.
  • Biflavonones are a class of natural compounds with diverse biological activities.

Purpose of the Study:

  • To isolate and characterize new chemical constituents from Coreopsis tinctoria.
  • To elucidate the structures of novel biflavonone compounds.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation employing Nuclear Magnetic Resonance (NMR) spectroscopy.
  • High-Resolution Electrospray Ionization Mass Spectrometry (HRESIMS) for molecular formula determination.
  • Circular Dichroism (CD) spectroscopy for stereochemical analysis.
Keywords:
CompositaeCoreopsis tinctoriabiflavononeschemical constituents

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Main Results:

  • Two new biflavonone compounds, designated sikokianin D (1) and sikokianin E (2), were successfully isolated.
  • The complete structures of compounds 1 and 2 were determined through comprehensive spectroscopic analysis.

Conclusions:

  • The study expands the knowledge of chemical diversity within the Coreopsis genus.
  • The identified compounds, sikokianin D and E, represent new additions to the known biflavonone family.
  • Further research may explore the biological activities of these novel compounds.