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Updated: May 31, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
Regulatory T cells as modulators of chronic allograft dysfunction
Fadi Issa1, Deepak Chandrasekharan, Kathryn J Wood
1Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, United Kingdom.
Regulatory T cells (Treg) show promise in preventing chronic allograft dysfunction (CAD) after organ transplants. Treg therapy, combined with tailored immunosuppression, may reduce reliance on drugs and improve long-term graft survival.
Area of Science:
- Immunology
- Transplantation Science
- Cellular Therapy
Background:
- Chronic allograft dysfunction (CAD) is a major cause of organ transplant failure.
- The adaptive immune system and long-term immunosuppression drive CAD pathogenesis.
- Regulatory T cells (Tregs) possess immune-suppressive capabilities.
Purpose of the Study:
- To explore the potential of Treg cellular therapy in managing CAD.
- To investigate Treg-friendly immunosuppressive strategies.
- To assess the feasibility of monitoring biomarkers for operational tolerance.
Main Methods:
- Review of experimental models of CAD using mouse and human Treg therapy.
- Analysis of the role of Tregs in clinically tolerant transplant recipients.
- Evaluation of immunosuppressive therapies that promote Treg function.
Main Results:
- Treg cellular therapy demonstrated efficacy in preventing some CAD manifestations in experimental models.
- Tregs play a role in established clinical tolerance.
- Certain immunosuppressive drugs support Treg activity.
Conclusions:
- Treg cellular therapy is a promising approach for mitigating CAD.
- Combining Treg therapy with tailored immunosuppression or drug weaning may be beneficial.
- Biomarker monitoring can guide personalized treatment strategies for operational tolerance.
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