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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
rac-Dimethyl 2-(1H-pyrrole-2-carboxamido)-butane-dioate
Le Zheng1, Fang Hu, Xiang Chao Zeng
1Department of Chemistry, Jinan University, Guangzhou, Guangdong 510632, People's Republic of China.
Abstract:
The title compound, C(11)H(14)N(2)O(5), was synthesized by condensation of (RS)-2-amino-succinic acid dimethyl ester with 2-trichloro-acetyl-pyrrole at room temperature. The amide group is twisted by 7.4 (1)° from the plane of the pyrrole ring. In the crystal, mol-ecules are linked by inter-molecular N-H⋯O hydrogen bonds into chains extending along the c axis.
