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Updated: May 31, 2026
11:01
Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
N,N'-Bis[(4-methyl-phen-yl)sulfon-yl]adipamide
Summary
This study details the crystal structure of a centrosymmetric compound, C(20)H(24)N(2)O(6)S(2). Intermolecular hydrogen bonds form zigzag chains, with one sulfur-oxygen bond being longer due to hydrogen bonding interactions.
Area of Science:
- Crystal chemistry
- Supramolecular chemistry
- Organic chemistry
Background:
- Understanding molecular interactions is crucial in crystal engineering.
- Hydrogen bonding plays a significant role in dictating crystal packing and properties.
- The study of organic compounds with sulfur and oxygen provides insights into their structural behavior.
Purpose of the Study:
- To elucidate the crystal structure of the title compound, C(20)H(24)N(2)O(6)S(2).
- To investigate the role of intermolecular hydrogen bonding in the self-assembly of molecules in the solid state.
- To analyze the influence of hydrogen bonding on bond lengths within the molecule.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of bond lengths, bond angles, and intermolecular interactions was performed.
- The crystal packing was visualized and analyzed to understand the arrangement of molecules.
Main Results:
- The title compound crystallizes in a centrosymmetric space group.
- Intermolecular N-H⋯O(S) hydrogen bonds were identified, linking molecules into zigzag chains along the b axis.
- A notable difference in S-O bond lengths was observed, with the hydrogen-bonded oxygen atom exhibiting a longer bond (1.441(2) Å) compared to the other (1.428(2) Å).
Conclusions:
- The crystal structure is stabilized by intermolecular N-H⋯O(S) hydrogen bonds, leading to the formation of 1D zigzag chains.
- The observed variation in S-O bond lengths is attributed to the influence of the intermolecular hydrogen bonding network.
- This study contributes to the understanding of structure-property relationships in organic crystals.
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