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Updated: May 31, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
4-Methyl-N-(2-methyl-phen-yl)benzamide.
This study details the crystal structure of a compound, C(15)H(15)NO, revealing two distinct molecular configurations and specific hydrogen bonding patterns. The findings contribute to understanding molecular arrangements in crystalline solids.
Area of Science:
- Crystallography
- Organic Chemistry
- Solid-State Chemistry
Background:
- Understanding the precise three-dimensional arrangement of atoms within a crystal is fundamental in chemistry.
- Molecular conformation and intermolecular interactions dictate the bulk properties of solid materials.
Purpose of the Study:
- To elucidate the crystal structure of the compound C(15)H(15)NO.
- To characterize the molecular conformations and hydrogen bonding networks present in the crystal lattice.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the atomic coordinates and unit cell parameters.
- Analysis of the crystal structure included examining dihedral angles, bond lengths, and hydrogen bonding interactions.
Main Results:
- The asymmetric unit contains two independent molecules with differing dihedral angles between aromatic rings (48.98(9)° and 57.48(8)°).
- Disordered methyl groups at para positions were observed, occupying two equally probable sites.
- Both intramolecular and intermolecular N-H⋯O hydrogen bonds were identified, forming chains along the b axis.
Conclusions:
- The crystal structure of C(15)H(15)NO exhibits molecular polymorphism within the asymmetric unit.
- Intermolecular hydrogen bonding plays a crucial role in stabilizing the crystal packing, leading to chain formation.
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