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Updated: May 31, 2026

Reproductive Techniques for Ovarian Monitoring and Control in Amphibians
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Published on: May 12, 2019

[PIBF - Progesterone-Induced Blocking Factor].

C Ermisch1, U R Markert

  • 1Placenta-Labor, Abteilung für Geburtshilfe, Klinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Jena.

Zeitschrift Fur Geburtshilfe Und Neonatologie
|July 15, 2011
PubMed
Summary
This summary is machine-generated.

Pregnancy involves unique maternal-fetal immune tolerance, supported by progesterone-induced blocking factor (PIBF). This factor is crucial for successful pregnancy and shows potential as a tumor biomarker for immune escape.

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Area of Science:

  • Reproductive Immunology
  • Maternal-Fetal Medicine
  • Immunology

Context:

  • Pregnancy represents a unique immunological state where maternal-fetal symbiosis occurs without rejection.
  • Key interfaces between mother and fetus include syncytiotrophoblast-covered villi, cytotrophoblast invasion, trophoblast cells in maternal arterioles, and circulating trophoblast particles.

Purpose:

  • To explore the role of progesterone-induced blocking factor (PIBF) in establishing maternal-fetal immunotolerance.
  • To investigate the implications of PIBF production by tumors for immune escape and therapeutic strategies.

Summary:

  • Progesterone-induced blocking factor (PIBF) is a 34 kDa protein released from lymphocytes under progesterone influence in healthy pregnancies.
  • PIBF exhibits immunomodulatory functions essential for maternal-fetal tolerance and normal pregnancy progression.
  • Tumors have been found to produce PIBF, aiding their immune evasion, suggesting potential as a novel tumor biomarker and therapeutic target.

Impact:

  • Understanding PIBF's role can enhance strategies for managing pregnancy complications related to immune rejection.
  • PIBF's involvement in tumor immune escape opens avenues for developing new cancer immunotherapies and diagnostic tools.