Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Protocol for the INterstitial lung Disease EXacerbations (INDEX) Study: a retrospective multicentre cohort study.

BMJ open respiratory research·2026

Same author

Polygenic risk and rare variants in endotypes of idiopathic pulmonary fibrosis: a genetic analysis of population-based and case-control cohorts.

The Lancet. Respiratory medicine·2026

Same author

Utilisation of cardiopulmonary exercise testing for tailored pulmonary rehabilitation in people with interstitial lung diseases: A systematic review.

Clinical rehabilitation·2025

Same author

The cyclic AMP paradox in pulmonary fibrosis: context is everything….

The European respiratory journal·2025

Same author

Comparative Viability and Functionality of Bio-Jetted and Threaded Human Umbilical Vein Endothelial Cells.

Small science·2025

Same author

Exploring the potential of cardiopulmonary exercise testing (CPET) for tailored pulmonary rehabilitation in people with interstitial lung disease (ILD): A systematic review protocol.

NIHR open research·2025

Same journal

AI-Derived Smart Microneedle Systems for Advanced Wound Management: From Intelligent Sensing to Closed-Loop Therapy.

Macromolecular bioscience·2026

Same journal

A Novel Chitosan-Gelatin Scaffold and Cell Spray Therapy for Treating Limbal Stem Cell Deficiency.

Macromolecular bioscience·2026

Same journal

Electroconductive Soft Microcarriers for Suspension Culture of Skeletal Muscle Cells.

Macromolecular bioscience·2026

Same journal

Dual-Responsive Chitosan-Grafted PNIPAAm Hydrogel Eye Drop Incorporating Insulin-Imprinted Microgels for Dry Eye Syndrome Treatment.

Macromolecular bioscience·2026

Same journal

Levan Inspired Hybrid Composites Materials: Bridging Natural Polysaccharides with Biomedical Technology.

Macromolecular bioscience·2026

Same journal

Anion-Specific Mechanisms in Fibrinogen Self-Assembly: Contrasting Effects of Phosphates and Chlorides in Nanofiber Formation.

Macromolecular bioscience·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 31, 2026

Bioengineering Human Microvascular Networks in Immunodeficient Mice

Bioengineering Human Microvascular Networks in Immunodeficient Mice

Published on: July 11, 2011

Bio-electrosprayed living composite matrix implanted into mouse models.

Suwan N Jayasinghe¹, Gary Warnes, Chris J Scotton

¹BioPhysics Group, Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, United Kingdom. s.jayasinghe@ucl.ac.uk

Macromolecular Bioscience

|July 15, 2011

Summary

This summary is machine-generated.

Bio-electrosprays create viable, cell-bearing tissue matrices. These living matrices integrate within the body, showing potential for tissue repair and rejuvenation.

More Related Videos

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Related Experiment Videos

Last Updated: May 31, 2026

Bioengineering Human Microvascular Networks in Immunodeficient Mice

Bioengineering Human Microvascular Networks in Immunodeficient Mice

Published on: July 11, 2011

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Developing methods for creating functional living tissues is crucial for regenerative medicine.
Existing techniques face challenges in replicating complex tissue architectures and ensuring cell viability.

Purpose of the Study:

To demonstrate the capability of bio-electrospray technology in generating composite de novo cell-bearing structures.
To assess the viability and in vivo integration of bio-electrosprayed matrices.
To validate the potential of bio-electrosprays and cell electrospinning for tissue repair and rejuvenation.

Main Methods:

Mouse lung fibroblasts were bio-electrosprayed with a biopolymer to form cell-bearing matrices.
In vitro assessments evaluated cellular behavior within the matrices.
In vivo studies involved subcutaneous implantation into murine hosts to evaluate matrix viability and integration.

Main Results:

Bio-electrospray successfully generated viable cell-bearing matrices.
In vitro tests confirmed expected cellular behaviors within the matrices.
Implanted matrices demonstrated successful integration with the host's microenvironment in vivo.

Conclusions:

Bio-electrospray is a viable method for creating functional, cell-bearing living architectures.
These engineered tissues show potential for subcutaneous implantation and integration.
The technology holds promise for applications in repairing, replacing, and rejuvenating damaged or aging tissues.