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Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
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Investigating Angiogenesis on a Functional and Molecular Level by Leveraging the Scratch Wound Migration Assay and the Spheroid Sprouting Assay
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Developmental and pathological angiogenesis.

Alicia S Chung1, Napoleone Ferrara

  • 1Genentech, Inc., South San Francisco, California 94080, USA.

Annual Review of Cell and Developmental Biology
|July 16, 2011
PubMed
Summary
This summary is machine-generated.

Vascular network formation is essential for vertebrate development, requiring coordinated cell responses to angiogenic cues. This review focuses on vascular endothelial growth factor (VEGF) signaling in blood vessel development and disease.

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Related Experiment Videos

Last Updated: May 31, 2026

Investigating Angiogenesis on a Functional and Molecular Level by Leveraging the Scratch Wound Migration Assay and the Spheroid Sprouting Assay
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Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
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Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

Area of Science:

  • Developmental Biology
  • Vascular Biology
  • Signaling Pathways

Background:

  • Vascular network formation is critical for vertebrate embryonic development, supplying oxygen and nutrients.
  • The cardiovascular system is the first functional organ, highlighting the vasculature's importance.
  • Precise patterning of branched conduits is necessary for embryonic tissue supply.

Purpose of the Study:

  • To review essential signaling pathways for vertebrate vasculature establishment.
  • To focus on vascular endothelial growth factor (VEGF) as a key regulatory factor.
  • To discuss physiological and pathological angiogenic processes, including tumorigenesis.

Main Methods:

  • Review of essential signaling pathways in vertebrate vascular development.
  • Focus on vascular endothelial growth factor (VEGF) and its role.
  • Discussion of angiogenic processes in physiological and pathological contexts.

Main Results:

  • Vascular development relies on coordinated endothelial and mural cell responses to angiogenic cues.
  • Aberrant regulation of angiogenic signals leads to developmental defects or disease.
  • VEGF is a key regulator in the establishment of the vertebrate vasculature.

Conclusions:

  • Understanding VEGF signaling is crucial for comprehending vascular development.
  • Disruptions in angiogenic processes contribute to diseases like cancer.
  • This review provides insights into the complex mechanisms of vascular formation and its implications.