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Related Concept Videos

Urologic Endoscopic Procedure: Cystoscopic Examination01:28

Urologic Endoscopic Procedure: Cystoscopic Examination

Meaning of Cystoscopic Examination:Cystoscopy is an essential diagnostic tool in urology that is used to assess the structure and function of the genitourinary system. It provides a direct view of the urethra, bladder, and, in some cases, the ureteral openings. This procedure helps detect structural abnormalities, infections, cancers, and blockages in the urinary tract. There are two types of cystoscopy:Flexible cystoscopy is commonly performed in outpatient settings due to its less invasive...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...

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Related Experiment Video

Updated: May 31, 2026

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
09:28

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Published on: May 12, 2019

[Urothelial hyperplastic lesion with endophytic growth pattern: a clinicopathologic study].

Li Xiao1, Chao-fu Wang, Xiong-zeng Zhu

  • 1Department of Pathology, Huadong Hospital, Fudan University, Shanghai 200040, China.

Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|July 16, 2011
PubMed
Summary

Endophytic urothelial lesions can be challenging to differentiate. Multitargeted fluorescence in situ hybridization (FISH) aids in distinguishing benign inverted papilloma from malignant urothelial carcinoma, improving diagnostic accuracy.

Related Experiment Videos

Last Updated: May 31, 2026

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
09:28

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Published on: May 12, 2019

Area of Science:

  • Uropathology
  • Oncology
  • Genetics

Context:

  • Urothelial lesions with endophytic growth patterns present diagnostic challenges.
  • Distinguishing benign from malignant lesions is crucial for appropriate patient management.

Purpose:

  • To investigate the clinicopathologic features of urothelial hyperplastic lesions with endophytic growth.
  • To evaluate the utility of immunohistochemistry and multitargeted fluorescence in situ hybridization (FISH) in differential diagnosis.

Summary:

  • Forty-one endophytic urothelial lesions were classified as inverted papilloma, urothelial carcinoma, or von Brunn nest.
  • Multitargeted FISH detected chromosomal abnormalities in 79.1% of urothelial carcinomas but not in benign lesions.
  • Immunohistochemistry for CK20, p53, and Ki-67 showed distinct patterns between benign and malignant entities.

Impact:

  • Histologic overlap between benign and malignant endophytic urothelial lesions necessitates advanced diagnostic tools.
  • Multitargeted FISH is a valuable adjunct for differentiating urothelial carcinoma with an endophytic growth pattern.
  • Findings contribute to improved diagnostic accuracy and patient outcomes in urothelial neoplasia.