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Plasma thrombomodulin concentration in diabetes mellitus.

K Oida1, H Takai, H Maeda

  • 1Third Department of Internal Medicine, Fukui Medical School, Japan.

Diabetes Research and Clinical Practice
|October 1, 1990
PubMed
Summary

Elevated plasma thrombomodulin levels in Type 2 diabetic patients correlate with kidney damage and retinopathy, indicating potential endothelial cell injury. These findings suggest circulating thrombomodulin as a biomarker for diabetic complications.

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Area of Science:

  • Endocrinology
  • Nephrology
  • Ophthalmology

Background:

  • Thrombomodulin is an endothelial cell membrane protein crucial for protein C activation.
  • Soluble thrombomodulin circulates in plasma, potentially indicating endothelial cell injury.
  • The role of circulating thrombomodulin in Type 2 diabetes requires further investigation.

Purpose of the Study:

  • To investigate plasma thrombomodulin concentrations in Type 2 diabetic patients.
  • To correlate thrombomodulin levels with markers of kidney function and diabetic retinopathy.

Main Methods:

  • Plasma thrombomodulin was quantified using a sandwich ELISA with monoclonal anti-thrombomodulin antibodies.
  • 106 Type 2 diabetic patients and control subjects were analyzed.
  • Correlations were assessed with proteinuria, serum creatinine, blood urea nitrogen, urinary albumin, urinary beta 2-microglobulin, and retinopathy status.

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Main Results:

  • Diabetic patients with proteinuria exhibited significantly higher plasma thrombomodulin than those without and controls.
  • Thrombomodulin levels positively correlated with markers of kidney dysfunction (creatinine, BUN, albuminuria, beta 2-microglobulin).
  • Elevated thrombomodulin was associated with pre-proliferative and proliferative retinopathy, even in patients without overt proteinuria.

Conclusions:

  • Plasma thrombomodulin is elevated in Type 2 diabetic patients, particularly those with proteinuria and retinopathy.
  • Circulating thrombomodulin may serve as a sensitive biomarker for endothelial dysfunction and kidney damage in diabetes.
  • Further research is warranted to elucidate the precise role of thrombomodulin in diabetic complications.