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Measurement of Tumor T2* Relaxation Times after Iron Oxide Nanoparticle Administration
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Two-dimensional T2 distribution mapping in porous solids with phase encode MRI.

Oleg V Petrov1, Bruce J Balcom

  • 1MRI Research Centre, Department of Physics, University of New Brunswick, Fredericton, Canada. opetrov@unb.ca

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|July 16, 2011
PubMed
Summary
This summary is machine-generated.

Two new MRI sequences, CPMG-prepared SPRITE and spin-echo SPI, enable 2-D T2 mapping for porous solids. These methods accurately measure short relaxation times, crucial for studying slow dynamic processes in materials science.

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Materials Science
  • Geophysics

Background:

  • Accurate T2 relaxation time measurements are vital for characterizing porous materials.
  • Existing 1-D MRI techniques have limitations for complex sample analysis.
  • Short relaxation times in porous solids pose challenges for conventional MRI.

Purpose of the Study:

  • To present two novel 2-D MRI sequences for T2 distribution mapping.
  • To extend 1-D MRI methods for enhanced analysis of porous media.
  • To enable the study of short relaxation times in various sample types.

Main Methods:

  • Development and implementation of CPMG-prepared SPRITE and spin-echo SPI sequences.
  • Two-dimensional (2-D) extension of previously described 1-D MRI techniques.
  • Testing on model samples and natural water-saturated rocks using a low-field MRI instrument.

Main Results:

  • Both 2-D spin-echo SPI and CPMG-SPRITE sequences demonstrated comparable performance.
  • The developed sequences can measure T2 values as low as 1-2 milliseconds.
  • Acquisition times were significant, ranging up to 2-2.5 hours per sample.

Conclusions:

  • The presented 2-D MRI sequences are effective for T2 mapping in samples with short relaxation times.
  • These techniques are suitable for studying slow dynamic processes under steady-state conditions.
  • Applications include enhanced oil recovery, cement hydration, and paramagnetic ion infiltration studies.