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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

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Related Experiment Video

Updated: May 31, 2026

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
10:02

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Published on: October 3, 2020

Elevated serum uric acid predicts chronic kidney disease.

Tamaki Yamada1, Mitsuru Fukatsu, Sadao Suzuki

  • 1Okazaki City Medical Association, Public Health Center, Aichi, Japan. t-yamada@okazaki-med.or.jp

The American Journal of the Medical Sciences
|July 16, 2011
PubMed
Summary

Elevated serum uric acid levels are a significant predictor of developing chronic kidney disease. This longitudinal study in Japanese adults shows higher uric acid increases kidney disease risk in both men and women.

Related Experiment Videos

Last Updated: May 31, 2026

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
10:02

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Published on: October 3, 2020

Area of Science:

  • Nephrology
  • Metabolic Health
  • Epidemiology

Background:

  • Elevated serum uric acid is a common metabolic abnormality.
  • Its role as an independent risk factor for chronic kidney disease (CKD) requires longitudinal assessment.
  • This study investigates the association in a Japanese population undergoing regular health checkups.

Purpose of the Study:

  • To determine if elevated serum uric acid is an independent, longitudinal risk factor for developing CKD.
  • To assess this risk in a large cohort of Japanese men and women.

Main Methods:

  • A cohort of 14,399 Japanese adults without hyperuricemia medication in 2000 was followed until 2005.
  • Participants with pre-existing CKD (eGFR <60 mL/min/1.73 m²) or treatments affecting uric acid were excluded.
  • Multivariable logistic regression analyzed factors for new CKD diagnosis in 2005, adjusting for age, BMI, blood pressure, lipids, glucose, urinary abnormalities, alcohol, and smoking.

Main Results:

  • Higher quartiles of serum uric acid correlated with increased prevalence of CKD and higher levels of BMI, blood pressure, and triglycerides.
  • CKD was newly diagnosed in 4.1% of men and 3.7% of women over the 5-year period.
  • Elevated serum uric acid quartiles significantly increased the risk of developing CKD in both sexes (ORs ranging from 1.32 to 1.42).

Conclusions:

  • Elevated serum uric acid is a significant independent predictor of incident chronic kidney disease.
  • This finding holds true for both men and women in the studied population.
  • Routine health checkups can identify individuals at risk for CKD based on serum uric acid levels.