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Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications
Published on: March 22, 2020
Cytotoxic gold(I)-bearing dendrimers from alkyne precursors
Thomas J Robilotto1, Daniel S Alt, Horst A von Recum
1Department of Chemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio, USA.
Dalton Transactions (Cambridge, England : 2003)
|July 16, 2011
Abstract:
A series of four dendrimers end-functionalized with gold(I) has been prepared from alkyne-terminated precursors and (tricyclohexylphosphine)gold(I) azide. Isolated yields range from 84-89%, based on gold. The first-generation dendrimer is cytotoxic toward 3T3 mouse fibroblast cells. Apoptosis ensues within 6 h of treatment with gold(I).

