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A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
Contact dermatitis caused by dimethylfumarate in Argentina
A Lo Balbo1, M J Gotelli, W P Mac Cormack
1Centro de Investigaciones Toxicológicas, Juan B. Alberdi 2986, Ciudad de Buenos Aires, Argentina. lbalbo55@yahoo.com
Clinical Toxicology (Philadelphia, Pa.)
|July 19, 2011
Summary
An outbreak of allergic contact dermatitis in Argentina was caused by new shoes. Dimethylfumarate was identified as the allergen, prompting a need for rapid detection methods.
Area of Science:
- Dermatology
- Toxicology
- Epidemiology
Background:
- Allergic contact dermatitis is a common skin reaction.
- Outbreaks can be linked to specific consumer products.
- Previous cases of dimethylfumarate exposure have been reported globally.
Observation:
- A cluster of patients in Argentina presented with severe foot dermatitis.
- Symptoms included intense itching, pain, edema, and blistering.
- The onset correlated with the use of new footwear.
Findings:
- Dimethylfumarate (DMF) was identified as the causative agent.
- The allergen was present in the new shoes worn by affected individuals.
- A rapid analytical method for DMF detection was proposed.
Implications:
- This is the first reported outbreak of DMF-induced contact dermatitis in Argentina.
- Highlights the importance of regulating chemicals in consumer goods like footwear.
- Emphasizes the need for accessible diagnostic tools for allergic reactions.
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
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