Related Experiment Video
Updated: May 31, 2026
11:06
Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
Published on: April 7, 2023
Plant phenylpropanoids as emerging anti-inflammatory agents
L Korkina1, V Kostyuk, C De Luca
1Lab. Tissue Engineering & Skin Pathophysiology, Istituto Dermopatico dell' Immacolata (IDI IRCCS), Via Monti di Creta 104, Rome 00167, Italy. l.korkina@idi.it
Mini Reviews in Medicinal Chemistry
|July 19, 2011
Summary
Plant-derived phenylpropanoids (PPPs) are key plant compounds offering protection and diverse medicinal benefits. This review explores their biosynthesis, anti-inflammatory properties, and challenges for drug development.
Area of Science:
- Plant biochemistry and medicinal chemistry.
- Focus on plant-derived phenylpropanoids (PPPs) and their derivatives.
Background:
- PPPs are vital plant secondary metabolites protecting against biotic and abiotic stresses.
- They are precursors to diverse polyphenols with essential roles in plant physiology.
- Extensive research targets PPPs for medicinal applications like antioxidants and anti-inflammatories.
Purpose of the Study:
- To review plant phenylpropanoid biosynthesis pathways and biotechnological reconstruction.
- To discuss the chemical properties of PPPs underlying their antioxidant and anti-inflammatory effects.
- To highlight the discovery of PPPs as anti-inflammatory agents and associated challenges.
Main Methods:
- Literature review of metabolic pathways and biotechnological systems.
- Analysis of chemical properties contributing to biological activity.
- Examination of in vitro and in vivo studies on PPPs' anti-inflammatory mechanisms.
Main Results:
- PPPs possess antioxidant, metal-chelating, and UV-protecting properties.
- Specific PPPs modulate inflammatory pathways in human cells and inhibit inflammation in vivo.
- Metabolic pathways can be reconstructed in engineered systems.
Conclusions:
- PPPs exhibit significant potential as anti-inflammatory agents.
- Understanding their chemical basis and biosynthetic pathways is crucial.
- Bioavailability, metabolism, and toxicity are key challenges for drug development.
Related Concept Videos
01:56Plant Hormones
Plant hormones—or phytohormones—are chemical molecules that modulate one or more physiological processes of a plant. In animals, hormones are often produced in specific glands and circulated via the circulatory system. However, plants lack hormone-producing glands.
01:56Plant Hormones
Plant hormones—or phytohormones—are chemical molecules that modulate one or more physiological processes of a plant. In animals, hormones are often produced in specific glands and circulated via the circulatory system. However, plants lack hormone-producing glands.
01:25Cell Signaling in Plants
Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
02:26Defenses Against Pathogens and Herbivores
Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
01:23Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
01:20Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...