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Updated: May 31, 2026

Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells
Published on: November 12, 2020
Beyond stereospecificity: liquids and mesoscale organization of cytoplasm
Anthony A Hyman1, Clifford P Brangwynne
1Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany. hyman@mpi-cbg.de
Abstract:
The cytoplasm is not a homogenous solution but instead consists of large dynamic assemblies that arise from transient molecular interactions. Some of these structures have been shown to represent liquid droplets of concentrated protein and RNA. Liquid phase separation of cytoplasm may be a fundamental principle of cytoplasmic organization.
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