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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

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Body weight gain and deep brain stimulation.

Isabelle Rieu1, Philippe Derost, Miguel Ulla

  • 1CHU Clermont-Ferrand, Neurology Department, Clermont-Ferrand, F-63001, France. irieu@chu-clermontferrand.fr

Journal of the Neurological Sciences
|July 19, 2011
PubMed
Summary

Deep brain stimulation (DBS) for Parkinson's disease can cause significant weight gain. This review explores the causes and health outcomes of weight changes in patients undergoing DBS therapy.

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Area of Science:

  • Neurosurgery
  • Neurology
  • Metabolic Medicine

Background:

  • Deep brain stimulation (DBS) is a 25-year-old neurosurgical treatment for motor and neuropsychiatric disorders.
  • Common targets include the thalamic ventralis intermedius nucleus (Vim), globus pallidus internus (GPi), and subthalamic nucleus (STN).
  • The subthalamic nucleus (STN) is a primary target for Parkinson's disease (PD) treatment.

Purpose of the Study:

  • To review current knowledge on weight changes in patients treated with DBS.
  • To describe the mechanisms underlying weight gain after DBS.
  • To discuss the health outcomes associated with weight changes post-DBS.

Main Methods:

  • Literature review of studies on DBS and weight changes.
  • Analysis of reported weight fluctuations in patients with various neurological disorders.
  • Examination of proposed physiopathological mechanisms for weight gain.

Main Results:

  • A rapid and marked weight gain is frequently observed in Parkinson's disease patients following STN-DBS.
  • This weight gain can lead to obesity and metabolic complications.
  • Weight changes are multifactorial, involving energy metabolism, eating behavior, and reduced motor complications.

Conclusions:

  • DBS, particularly STN-DBS for PD, is associated with significant weight gain.
  • Understanding the mechanisms is crucial for managing metabolic health outcomes.
  • Further research is needed to optimize DBS therapy and mitigate adverse weight effects.