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Mandibular osteomyelitis associated with paroxysmal nocturnal hemoglobinuria
M Kharazmi1, K Carlson, L Björnstad
1Department of Oral and Maxillofacial Surgery, Central Hospital, Västerås, Sweden.
International Journal of Oral and Maxillofacial Surgery
|July 19, 2011
Summary
This report details a rare case of osteomyelitis in a patient with paroxysmal nocturnal hemoglobinuria (PNH). It suggests a potential link between PNH and mandibular osteomyelitis, a condition typically seen in other hemolytic disorders.
Area of Science:
- Oral and Maxillofacial Surgery
- Hematology
- Infectious Diseases
Background:
- Osteomyelitis of the jaw is a significant cause of morbidity in the oral and maxillofacial region.
- Vaso-occlusive crises in sickle cell anemia, a hemolytic disorder, are known to predispose patients to jaw osteomyelitis.
- Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hemolytic anemia.
Observation:
- A case of osteomyelitis affecting the mandible in a 71-year-old female patient with a history of PNH is presented.
- The patient's presentation and diagnostic findings are detailed.
Findings:
- The case report proposes a potential association between paroxysmal nocturnal hemoglobinuria (PNH) and the development of osteomyelitis of the mandible.
- This finding expands the understanding of predisposing factors for jaw osteomyelitis beyond well-established conditions like sickle cell anemia.
Implications:
- This case highlights the need to consider PNH as a potential risk factor for mandibular osteomyelitis.
- Further research may be warranted to elucidate the mechanisms underlying this association.
- Clinicians should maintain a high index of suspicion for osteomyelitis in PNH patients presenting with relevant symptoms.
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