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Conducting Multiple Imaging Modes with One Fluorescence Microscope

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Novel Multiplexer to Enable Multiple-Module Imaging with Adjustable High Spatial Resolution and Predetermined Display

P Sharma¹, A H Titus, B Qu

¹P. Sharma, A.H Titus, B. Qu, Y. Huang, W. Wang, A. N. Cartwright, D. R. Bednarek and S. Rudin are with the Electrical Engineering Department and Toshiba Stroke Research Center at University at Buffalo, The State University of New York, Buffalo, NY 14260-1920, USA.

IEEE Nuclear Science Symposium Conference Record. Nuclear Science Symposium

|September 28, 2011

Summary

A new integrated circuit, the multiple-module multiplexer integrated circuit (MMMIC), combines Electron multiplying charge coupled devices (EMCCD) for enhanced medical imaging. This circuit enables larger fields of view and adjustable resolution for clinical applications.

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Area of Science:

Medical Imaging Technology
Integrated Circuit Design
Photonics and Detector Systems

Background:

Current medical imaging systems require flexible solutions for high spatial resolution over specific regions of interest and adequate field of view.
Dynamic imaging systems are needed to maintain acquisition bandwidth regardless of the field of view size.
Combining discrete imaging modules offers a path to improved imaging system flexibility and performance.

Purpose of the Study:

To introduce a custom multiple-module multiplexer integrated circuit (MMMIC) for enhancing medical imaging systems.
To enable the combination of discrete Electron multiplying charge coupled devices (EMCCD) based imaging modules.
To achieve flexible imaging with high spatial resolution, large fields of view, and dynamic acquisition bandwidth.

Main Methods:

Designed and fabricated a custom MMMIC using the ON-SEMI 0.5microm CMOS process.
Implemented multiplexing of imaging module outputs for larger fields of view.
Incorporated binning modes for adjustable spatial resolution and module selection for region of interest (ROI) imaging.
Developed a modular design allowing cascading of MMMICs for larger imaging arrays.

Main Results:

The prototype MMMIC successfully multiplexed outputs from EMCCD-based detectors.
Demonstrated the ability to control three discrete imager arrays with a single MMMIC.
Showcased a two-stage arrangement of four MMMICs to readout a 3x3 array of imaging modules.
Validated the MMMIC's functionality in an x-ray imaging array detector system.

Conclusions:

The MMMIC effectively combines discrete EMCCD imaging modules to create flexible, high-performance medical imaging systems.
The modular design allows for scalable imaging arrays (M×N) with large fields of view, ROI imaging, and adjustable spatial resolution.
This integrated circuit provides a significant advancement for dynamic and adaptable medical imaging solutions.