Related Experiment Video
Updated: Jun 7, 2025
06:11
Arterial Pouch Microsurgical Bifurcation Aneurysm Model in the Rabbit
Published on: May 14, 2020
2.3K
Demonstration of 1000 fps High-Speed Angiography (HSA) in Pre-Clinical In-vivo Rabbit Aneurysm Models During
E A Vanderbilt1, C Koenighsknecht1, D Pionessa1
1University of Buffalo, Buffalo, New York, USA, Canon Research Stroke and Vascular Center, Buffalo, New York, USA.
Proceedings of Spie--The International Society for Optical Engineering
|November 14, 2024
Summary
High Speed Angiography (HSA) visualizes blood flow changes before and after flow-diverter treatment in rabbit aneurysm models. This novel technique offers detailed insights into vascular dynamics, aiding in the assessment of treatment efficacy.
Area of Science:
- Biomedical Engineering
- Medical Imaging
- Interventional Radiology
Background:
- High Speed Angiography (HSA) at 1000 frames per second (fps) has shown promise in visualizing vascular flow dynamics in in-vitro models.
- Previous studies utilized HSA for flow-diverter treatment assessment in 3D printed cerebral aneurysm models.
Purpose of the Study:
- To demonstrate the feasibility and application of HSA in an in-vivo pre-clinical setting for evaluating flow-diverter treatment of cerebral aneurysms.
- To visualize and quantitatively analyze changes in blood flow patterns before and after flow-diverter placement in rabbit carotid artery aneurysm models.
Main Methods:
- Aneurysms were created in rabbit common carotid arteries using elastase methods.
- Flow-diverter stents were deployed in the parent vessel under standard fluoroscopy guidance.
- High Speed Angiography (1000 fps) using a photon-counting detector was performed pre- and post-stent deployment.
- Contrast agent was injected, and image acquisition was synchronized with x-ray exposure for detailed flow visualization.
- Optical Flow (OF) analysis was applied to HSA sequences for quantitative velocity assessment.
Main Results:
- HSA successfully visualized detailed differences in blood flow patterns within the aneurysm and parent vessel before and after flow-diverter placement.
- The technique provided high-resolution imaging of vascular dynamics, enabling clear observation of flow diversion.
- Quantitative analysis using Optical Flow provided velocity data, complementing the visual assessment of treatment impact.
Conclusions:
- High Speed Angiography is a viable and effective pre-clinical tool for evaluating the hemodynamic effects of flow-diverter treatment in-vivo.
- This technique offers enhanced visualization and quantitative analysis of blood flow, crucial for assessing the efficacy of endovascular treatments for aneurysms.
