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Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis
Published on: July 8, 2025
Molecular sensitivity of DNA-Ag-PATP hybrid on optical activity for ultratrace mercury analysis
Honglin Liu1, Liangbao Yang, Hongwei Ma
1Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei 230031, China.
Chemical Communications (Cambridge, England)
|July 19, 2011
Abstract:
The para-aminothiophenol (PATP), in which the thiol groups adsorbed on the Ag surface and the amino groups coordinated with Hg(2+), can mediate the aggregation of sunlight-reduced λ-DNA-templated Ag nanoparticles, resulting in high molecular sensitivity of this hybrid on optical activity. Sub-pM levels of Hg(2+) assays were achieved based on this molecular stepwise assembly.
