Related Experiment Video
Updated: May 31, 2026

10:54
Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol
Published on: November 21, 2025
A stepped care relapse prevention program for depression in older people: a randomized controlled trial
Sachlan R A Apil1, Erik Hoencamp, P M Judith Haffmans
1Leiden University Institute of Psychology, Leiden, the Netherlands. sapil@fsw.leidenuniv.nl
International Journal of Geriatric Psychiatry
|July 19, 2011
Summary
The Stepped Care Program (SCP) did not prevent depression relapse in older adults compared to usual care. Early intervention is crucial, as watchful waiting may delay necessary preventive treatment.
Area of Science:
- Gerontology
- Psychiatry
- Clinical Psychology
Background:
- Depression relapse is a significant concern in older adults.
- A Stepped Care Program (SCP) involving watchful waiting, bibliotherapy, cognitive behavioral therapy, and indicated treatment was evaluated.
- The study focused on the feasibility and effectiveness of SCP for depression relapse prevention in individuals aged 55 and older.
Purpose of the Study:
- To determine the feasibility and effectiveness of a Stepped Care Program (SCP) for preventing depression relapse in older adults.
- To compare the incidence of new depressive episodes between SCP and Care As Usual (CAU) in a randomized controlled trial.
Main Methods:
- A randomized controlled trial was conducted with 136 participants aged 55 years and older with a history of major depression.
- Participants were assigned to either the SCP or Care As Usual (CAU) group.
- The primary outcome was the incidence of a new depressive episode over a 12-month follow-up period.
Main Results:
- Treatment satisfaction with the SCP was high among participants.
- No statistically significant difference in the incidence of depression was observed between the SCP and CAU groups at 12-month follow-up.
- Analysis of medical records indicated that missing data were often associated with depressive relapse.
Conclusions:
- The Stepped Care Program (SCP) was not more effective than Care As Usual (CAU) in preventing depression relapse in older adults.
- The 'watchful waiting' component of the SCP may delay essential preventive interventions, potentially causing harm.
- Integrating depression prevention into routine treatment could improve participation rates.
Related Concept Videos
Depression: Overview
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Alzheimer's Disease: Treatment
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
Depressive Disorders: MDD and Dysthymia
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
Dosage Regimens: Designs and Approaches
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
Long-term Depression
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Long-term Depression
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Calcium Ion Concentration Mechanism
If over time, all...