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Weight gain in infancy and post-bronchiolitis wheezing

Kirsi Nuolivirta1, Petri Koponen, Merja Helminen

  • 1Seinäjoki Central Hospital, Finland.

Acta Paediatrica (Oslo, Norway : 1992)
|July 20, 2011
PubMed

Insights

High birth weight and infant overweight are linked to wheezing after bronchiolitis. This study examined birth weight, infant weight gain, and weight-for-length (WFL) as risk factors for post-bronchiolitis wheezing.

Area of Science:

  • Pediatrics
  • Respiratory Medicine
  • Epidemiology

Background:

  • Birth weight and infant weight changes are potential risk factors for childhood asthma.
  • Associations between birth weight, infant weight gain, and early childhood wheezing, particularly post-bronchiolitis, require further investigation.

Purpose of the Study:

  • To assess birth weight, infant weight gain, and infant overweight (using weight-for-length, WFL) as risk factors for wheezing after hospitalization for bronchiolitis.

Main Methods:

  • A cohort of 127 infants hospitalized for bronchiolitis before 6 months of age was followed until 1.5 years.
  • Infant weights and lengths were measured on admission and at follow-up; birth weights were obtained from records.

Main Results:

  • High birth weight (>4000 g) was associated with both the occurrence and recurrence of post-bronchiolitis wheezing.
  • Infant overweight (WFL >110%) at 1.5 years correlated with recurrent wheezing.
  • Increased weight gain from birth to hospitalization (<6 months) was linked to wheezing in infants with high birth weight.

Conclusions:

  • High birth weight and developing overweight in infancy may be associated with post-bronchiolitis wheezing.
  • These findings highlight the potential role of early-life growth patterns in respiratory health outcomes.
Abstract

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