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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

What is Cancer?

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...

What is Cancer?

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Cancers Originate from Somatic Mutations in a Single Cell

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

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Related Experiment Video

Updated: May 30, 2026

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

Cancer and itch.

Herbert C Chiang¹, Victor Huang, Lynn A Cornelius

¹Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Seminars in Cutaneous Medicine and Surgery

|July 20, 2011

Summary

This summary is machine-generated.

Cancer-related itch is a common problem. This review covers causes, mechanisms, and treatments for itch in cancer patients, including leukemia and lymphoma.

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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

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Published on: December 19, 2019

Area of Science:

Oncology
Dermatology
Pathophysiology

Background:

Itch (pruritus) is a frequent and debilitating symptom in cancer patients.
Itch can be directly linked to hematologic malignancies like leukemia and lymphoma.
Malignancy can also cause itch indirectly through organ dysfunction (hepatic, renal) or as a side effect of cancer treatments.

Purpose of the Study:

To review the clinical presentations of itch in oncological patients.
To summarize current knowledge on the molecular and cellular basis of malignancy-associated itch.
To discuss available therapeutic strategies for managing itch in this population.

Main Methods:

Literature review of clinical scenarios and mechanisms of cancer-related itch.
Synthesis of information on pathophysiology and treatment options.
Focus on common malignancies (leukemia, lymphoma) and treatment-induced pruritus.

Main Results:

Itch in cancer patients has diverse origins: direct malignancy, organ dysfunction, or treatment side effects.
Understanding the underlying mechanisms is crucial for effective management.
Various therapeutic approaches exist, tailored to the specific cause of itch.

Conclusions:

Malignancy-related itch requires a comprehensive approach, considering direct and indirect causes.
Further research into the pathophysiology may yield novel therapeutic targets.
Effective management of itch improves patient quality of life during cancer treatment.