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Related Experiment Video

Updated: May 30, 2026

Quantitation of Endothelial Cell Adhesiveness In Vitro
10:24

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Published on: June 18, 2015

CD31+ T cells, endothelial function and cardiovascular risk.

Brian R Weil1, Erich J Kushner, Kyle J Diehl

  • 1Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.

Heart, Lung & Circulation
|July 20, 2011
PubMed
Summary
This summary is machine-generated.

CD31(+) T cell function, not number, is linked to endothelial function and cardiovascular disease risk in healthy men. Enhanced T cell migration to SDF-1α and VEGF indicates better vascular health.

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Published on: January 28, 2020

Area of Science:

  • Immunology
  • Cardiovascular Science
  • Vascular Biology

Background:

  • Endothelial cell repair deficits contribute to endothelial dysfunction and cardiovascular disease (CVD).
  • CD31(+) T cells, or 'angiogenic T cells,' possess favorable vascular properties and correlate inversely with atherosclerotic disease severity.
  • The relationship between CD31(+) T cell number/function and endothelial function/CVD risk in healthy adults remains unclear.

Purpose of the Study:

  • To investigate the association between CD31(+) T cell number and function with endothelial function and CVD risk in healthy adult men.

Main Methods:

  • 24 healthy adult men (ages 21-70) were studied.
  • Endothelial function assessed via forearm blood flow (FBF) response to acetylcholine (ACh).
  • Cardiovascular disease risk estimated using Framingham Risk Score (FRS); CD31(+) T cell number determined by flow cytometry; cell migration assessed via Boyden chamber assays.

Main Results:

  • No correlation was found between CD31(+) T cell number and FBF response to ACh or FRS.
  • CD31(+) T cell migration to stromal cell-derived factor (SDF)-1α and vascular endothelial growth factor (VEGF) positively correlated with FBF response to ACh (r=0.43-0.38, P<0.05).
  • CD31(+) T cell migration inversely correlated with FRS (r=-0.53 to -0.48, P<0.05).

Conclusions:

  • CD31(+) T cell function, specifically their migratory capacity towards SDF-1α and VEGF, is associated with in vivo endothelial function.
  • Enhanced CD31(+) T cell migration is linked to a reduced cardiovascular disease risk in healthy men.
  • These findings highlight the functional importance of CD31(+) T cells in maintaining vascular health.