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Viral Structure

Viral Structure

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.

Size and Structure of Viral Genomes

Size and Structure of Viral Genomes

Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...

Protein and Protein Structures

Protein and Protein Structures

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...

Subviral Agents

Subviral Agents

Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...

Protein Organization

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

Protein Organization

Protein Organization

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Related Experiment Video

Updated: May 30, 2026

An Assay for Quantifying Protein-RNA Binding in Bacteria

An Assay for Quantifying Protein-RNA Binding in Bacteria

Published on: June 12, 2019

VPDB: Viral Protein Structural Database.

Om Prakash Sharma¹, Ankush Jadhav, Afzal Hussain

¹Centre for Bioinformatics, School of Life Sciences, Pondicherry University, Pondicherry-605014, India.

|July 20, 2011

Summary

The Viral Protein Database (VPDB) offers interactive 3D viral protein structures for structural virology research. It provides access to over 1,670 viral protein structures from numerous viruses and strains.

Keywords:

Database Jmol STRAP WebMol viral proteins virus

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Area of Science:

Structural biology
Virology
Bioinformatics

Background:

The Viral Protein Database (VPDB) is an interactive resource.
It focuses on derived data from structural biology studies.

Purpose of the Study:

To provide a comprehensive resource for the structural virology community.
To offer easy access to 3D viral protein structures and related data.

Main Methods:

Data compilation of viral protein structures.
Development of an interactive database.
Integration of visualization tools like Jmol, WebMol, and Strap.

Main Results:

VPDB currently contains approximately 1,670 viral protein structures.
These structures represent over 277 viruses and more than 465 virus strains.
The database features user-friendly text search and interactive molecular visualization.

Conclusions:

VPDB serves as a valuable, accessible resource for researchers in structural virology.
The interactive visualization tools enhance the exploration of viral protein molecular structures.