Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regulatory T cells epigenetically reprogrammed from autoreactive effector T cells mitigate established autoimmunity.

bioRxiv : the preprint server for biology·2025
Same author

Tregs epigenetically reprogrammed from autoreactive effector T cells mitigate established autoimmunity.

JCI insight·2025
Same author

Nonclinical teratogenicity safety assessment of CRBN-engaging targeted protein degraders: Points to consider.

Regulatory toxicology and pharmacology : RTP·2025
Same author

Do longer duration nonclinical toxicology studies provide predictive clinical safety value? The IQ consortium longer duration nonclinical to clinical translational database.

Toxicology and applied pharmacology·2024
Same author

FDA and industry collaboration: Identifying opportunities to further reduce reliance on nonhuman primates for nonclinical safety evaluations.

Regulatory toxicology and pharmacology : RTP·2022
Same author

Physician satisfaction with telemedicine and in-person visits in otolaryngology.

American journal of otolaryngology·2022

Related Experiment Video

Updated: Dec 22, 2025

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells
05:45

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Published on: October 10, 2025

402

Overview: developmental toxicology: new directions.

Dana Shuey1, James H Kim

  • 1Endo Pharmaceuticals, Inc, Chadds Ford, Pennsylvania, USA.

Birth Defects Research. Part B, Developmental and Reproductive Toxicology
|July 20, 2011
PubMed
Summary
This summary is machine-generated.

Standardized developmental toxicology protocols, born from the thalidomide tragedy, have advanced chemical safety. However, new methods are needed for risk assessment and alternatives to animal testing.

More Related Videos

Assessment of Chemical Toxicity in Adult Drosophila Melanogaster
07:02

Assessment of Chemical Toxicity in Adult Drosophila Melanogaster

Published on: March 24, 2023

4.0K
Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

13.0K

Related Experiment Videos

Last Updated: Dec 22, 2025

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells
05:45

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Published on: October 10, 2025

402
Assessment of Chemical Toxicity in Adult Drosophila Melanogaster
07:02

Assessment of Chemical Toxicity in Adult Drosophila Melanogaster

Published on: March 24, 2023

4.0K
Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

13.0K

Area of Science:

  • Toxicology
  • Developmental Biology
  • Risk Assessment

Background:

  • Standardized developmental toxicology protocols were established in the mid-1960s following the thalidomide tragedy.
  • These protocols have significantly advanced chemical and pharmaceutical safety and risk assessment.
  • The field has excelled in hazard identification but requires improved methodologies for human health risk assessment.

Discussion:

  • A workshop, "Developmental Toxicology-New Directions," convened scientists, researchers, and regulators.
  • The workshop evaluated 30 years of developmental toxicology and discussed future testing strategies.
  • Discussions focused on challenges in assessing risks from environmental chemicals and the need for alternatives to animal testing.

Key Insights:

  • Exponential growth in knowledge of embryo-fetal development and experimental technologies.
  • Success in preventing tragedies similar to thalidomide through established testing protocols.
  • Urgent need for enhanced methodologies in human health risk assessment, especially for environmental chemicals.

Outlook:

  • Exploring new directions in developmental toxicology testing.
  • Developing better alternatives to whole animal testing.
  • Integrating new approaches for comprehensive chemical safety evaluation.