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Updated: May 30, 2026

A Modular Workflow for Quantitative, Structural and Functional Analysis of Leptospira Biofilms
Published on: December 19, 2025
A modular synthesis of salvileucalin B structural domains
Chih-Chung Tseng1, Hanfeng Ding, Ang Li
1Chemical Synthesis Laboratory@Biopolis, Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, The Helios Block, #03-08, Singapore 138667.
Abstract:
A modular strategy leading to the salvileucalin B core structure has been accomplished. The developed synthetic strategy featured a bioinspired intramolecular Diels-Alder reaction to construct domain "A", REDOX chemistry to functionalize domain "B", and a palladium-mediated cross-coupling to install domain "C". This flexible approach should facilitate further chemical and biological investigations of this fascinating class of compounds.
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