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Updated: May 30, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Synthesis and biological evaluation of orally active hypolipidemic agents
Babasaheb P Bandgar1, Rajendra J Sarangdhar, Fruthous Khan
1Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur-413 255, India. bandgar_bp@yahoo.com
Abstract:
A series of novel fenofibric acid ester prodrugs 1c-1h were synthesized and evaluated with the aim of obtaining potent hypolipidemic agents. Prodrugs 1c and 1d exhibited potent hypochlolesterolemic activity, lowering the mice plasma triglyceride level up to 47% in Swiss albino mice after oral administration of 50 mg/kg/day for 8 days. Fenofibric acid ester prodrugs 1c-1h were found lipophilic like fenofibrate (1b), indicated by partition coefficients measured in octanol-buffer system at pH 7.4. On the basis of in vivo studies, prodrugs 1c and 1d emerged as potent hypolipidemic agents.
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