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Non-chromatographic Purification of Recombinant Elastin-like Polypeptides and their Fusions with Peptides and Proteins from Escherichia coli
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Eribulin.

Caroline M Perry1

  • 1Adis, a Wolters Kluwer Business, Auckland, New Zealand. demail@adis.co.nz

Drugs
|July 21, 2011
PubMed
Summary
This summary is machine-generated.

Eribulin significantly improved overall survival in patients with advanced breast cancer previously treated with anthracyclines and taxanes. This microtubule inhibitor demonstrated a manageable safety profile in the EMBRACE trial.

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Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Eribulin mesylate is a non-taxane microtubule dynamics inhibitor used for metastatic breast cancer.
  • It has shown antiproliferative activity in vitro and tumor regression in xenograft models.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of eribulin in patients with locally recurrent or metastatic breast cancer previously treated with anthracyclines and taxanes.

Main Methods:

  • A randomized, open-label, multinational, phase III EMBRACE trial.
  • Compared intravenous eribulin (n=508) with physician's choice of treatment (n=254) in heavily pre-treated patients.

Main Results:

  • Median overall survival was significantly longer with eribulin (13.1 months) versus physician's choice (10.6 months; HR 0.81, p=0.041).
  • Eribulin demonstrated a manageable tolerability profile.
  • Peripheral neuropathy was the most common adverse event leading to discontinuation (5%).

Conclusions:

  • Eribulin offers a significant survival benefit for patients with advanced breast cancer after prior anthracycline and taxane treatment.
  • The drug has a manageable safety profile, with peripheral neuropathy as a key adverse event to monitor.