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Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
Acute disseminated encephalomyelitis preceding measles exanthema
Raffaele Nardone1, Stefan Golaszewski, Eugen Trinka
1Franz Tappeiner Hospital, Merano, Italy. raffaele.nardone@asbmeran-o.it
Journal of Child Neurology
|July 21, 2011
Summary
Acute disseminated encephalomyelitis (ADEM) can precede measles infection, with brain imaging showing abnormalities before symptoms appear. This suggests immune-mediated demyelination may occur early in viral infections.
Area of Science:
- Neurology
- Infectious Diseases
- Immunology
Background:
- Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease.
- Measles virus infection is a common trigger for various neurological complications.
Observation:
- A case presented with ADEM symptoms and brain MRI findings before the onset of measles virus infection.
- Clinical manifestations of measles, including fever and Koplik spots, appeared 8-10 days after initial ADEM signs.
Findings:
- The case supports the hypothesis that immune-mediated demyelination can precede the symptomatic phase of viral infections.
- Brain MRI revealed signal abnormalities in the basal ganglia and cortex indicative of ADEM.
Implications:
- ADEM should be considered in the differential diagnosis of children presenting with neurological symptoms, even without a prior history of infectious disorders.
- Early recognition of ADEM may be crucial for timely intervention in potential post-infectious neurological complications.
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