Epidermolytic hyperkeratosis in inflammatory linear verrucous epidermal nevus

Area of Science:

• Dermatology
• Pathology

Background:

• Epidermolytic hyperkeratosis is a recognized histopathological pattern observed in various skin conditions.
• This pattern is characterized by specific cellular changes in the epidermis, including perinuclear vacuolization and altered granule formation.

Purpose of the Study:

• To report the first case of epidermolytic hyperkeratosis occurring in inflammatory linear verrucous epidermal nevus.
• To document the clinical and histopathological findings of this rare presentation.

Main Methods:

• Case presentation of a 23-year-old male with a 13-year history of pruritic, verrucous lesions.
• Clinical examination revealing linear hyperkeratotic and epidermal nevus lesions.
• Microscopic examination of lesional skin demonstrating psoriasiform acanthosis, hyperkeratosis, and epidermolytic changes.

Main Results:

• The patient presented with characteristic features of inflammatory linear verrucous epidermal nevus.
• Histopathological analysis confirmed the presence of epidermolytic hyperkeratosis, alongside other reactive changes like psoriasiform acanthosis and perivascular inflammation.
• No systemic involvement was detected.

Conclusions:

• This study establishes a novel association between epidermolytic hyperkeratosis and inflammatory linear verrucous epidermal nevus.
• The findings broaden the spectrum of conditions associated with the epidermolytic hyperkeratosis pattern.
• This highlights the importance of thorough histopathological evaluation in diagnosing complex dermatoses.