Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antidepressant Drugs: MAOIs and Other Agents

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...

Bipolar Disorder

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.

Mania and Antimanic Drugs: Overview

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...

Antidepressant Drugs: Overview

Antidepressant Drugs: Overview

Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...

Depressive Disorders: MDD and Dysthymia

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cognitive remediation and schizophrenia: Effects on brain complexity.

Neuroscience letters·2023

Same author

Psychosocial intervention model for migrant workers during extended lockdown: The Chandigarh model.

Indian journal of psychiatry·2021

Same author

Factors Leading to Reverse Migration Among Migrant Workers During the COVID-19 Pandemic: A Multicenter Study From Northwest India.

The primary care companion for CNS disorders·2021

Same author

Psychiatric morbidity and substance use in migrant workers: A population based study.

The International journal of social psychiatry·2021

Same author

Migrant Workers' Needs and Perceptions While Lodged in a Shelter Home in India During the COVID-19 Pandemic.

The primary care companion for CNS disorders·2020

Same author

Efforts to Minimize the Impact of Lockdown on Migrant Workers in India During the COVID-19 Pandemic.

The primary care companion for CNS disorders·2020

Search research articles

Related Experiment Video

Updated: May 30, 2026

The Forced Swim Test as a Model of Depressive-like Behavior

The Forced Swim Test as a Model of Depressive-like Behavior

Published on: March 2, 2015

Fluoxetine induced hypomania - a case report.

¹Assistant Professor, Department of Psychiatry, AIIMS, New Delhi.

Indian Journal of Psychiatry

|July 22, 2011

Summary

This summary is machine-generated.

Fluoxetine may trigger mania in individuals with a predisposition, such as a family history of affective disorder or prior affective illness. High fluoxetine doses also appear to be a contributing factor in these cases.

Related Experiment Videos

Last Updated: May 30, 2026

The Forced Swim Test as a Model of Depressive-like Behavior

The Forced Swim Test as a Model of Depressive-like Behavior

Published on: March 2, 2015

Area of Science:

Psychiatry
Pharmacology

Background:

Recent literature highlights numerous cases of Fluoxetine-induced mania.
Analysis of case reports suggests pre-existing vulnerabilities in affected patients.

Purpose of the Study:

To analyze reported cases of Fluoxetine-induced mania.
To identify risk factors associated with Fluoxetine-induced mania.

Main Methods:

Review and analysis of existing case reports on Fluoxetine-induced mania.

Main Results:

Patients experiencing Fluoxetine-induced mania often had a positive family history of affective disorder.
A past history of affective illness was frequently observed in these patients.
High doses of Fluoxetine were also linked to the precipitation of manic episodes.

Conclusions:

Fluoxetine may precipitate mania in susceptible individuals with genetic predispositions.
Alternatively, mania may occur naturally in patients with a history of affective disorder, irrespective of Fluoxetine use.