Fluoxetine induced hypomania - a case report

Recently, many cases of Fluoxetine induced mania have been reported in the literature. The detailed analysis of these case reports demonstrates that these patients had either positive family history of affective disorder (Lebegne, 1987), past history of affective illness (Settle and Settle, 1984; Lebegne, 1987; Nakra el al., 1989) or were related to high doses of fluoxetine (Chouinard and Steiner, 1986., Turner et al., 1988). Fluoxetine might have precipitated mania in susceptiple individuals (genetic loading) or mania might have developed naturally at that time even without fluoxetine (patients with past history of affective disorder) in these patients.