Increasing the antibacterial effect of lysozyme by immobilization on multi-walled carbon nanotubes
Daniele Merli1, Monica Ugonino, Antonella Profumo
1Department of General Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.
Journal of Nanoscience and Nanotechnology
|July 23, 2011
Abstract:
We report a facile strategy to obtain multiwalled carbon nanotubes (MWCNTs) functionalized with covalently bonded lysozyme. The functionalization procedure has been investigated by means of several techniques, including thermogravimetry, Raman spectroscopy, transmission electron microscopy, and cyclic voltammetry. A functionalization of about 1 lysozyme molecule every 4000 carbon atoms is obtained. The modified lysozyme-CNTs nanocomposite shows a significant increase of the antibacterial activity towards the Gram-positive S. aureus if compared with lysozyme in solution.


