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Related Experiment Video

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MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
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Published on: December 13, 2017

Non-motor features in essential tremor.

V Chandran1, P K Pal, J Y C Reddy

  • 1Department of Neurology, National Institute of Mental Health & Neurosciences, Bangalore, India.

Acta Neurologica Scandinavica
|July 23, 2011
PubMed
Summary
This summary is machine-generated.

Essential tremor (ET) patients experience more sleep issues, fatigue, pain, anxiety, and depression than healthy individuals. Depression significantly impacts their quality of life.

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Area of Science:

  • Neurology
  • Clinical Psychology

Background:

  • Essential tremor (ET) is increasingly recognized for its non-motor symptoms.
  • Understanding these manifestations is crucial for comprehensive patient care.

Purpose of the Study:

  • To determine the prevalence of non-motor manifestations in ET patients.
  • To assess the impact of these non-motor symptoms on the quality of life (QOL) in ET.

Main Methods:

  • A cross-sectional, case-control, questionnaire-based study.
  • 50 ET patients and 50 matched healthy controls were assessed.
  • Standardized scales measured sleep quality, fatigue, pain, anxiety, and depression.

Main Results:

  • ET patients showed significantly higher rates of sleep disturbances (46% vs 8%), fatigue (30% vs 8%), anxiety (66% vs 18%), and depression (44% vs 8%).
  • ET patients also reported higher pain severity and interference.
  • Hierarchical regression revealed depression as the sole non-motor factor significantly affecting QOL.

Conclusions:

  • Essential tremor is associated with a higher prevalence and severity of sleep disturbances, fatigue, pain, anxiety, and depression.
  • Depression is a significant determinant of reduced quality of life in individuals with ET.