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Movement Retraining using Real-time Feedback of Performance
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Published on: January 17, 2013

Novel strategies for improving physical function.

Shalender Bhasin1, Ravi Jasuja, Powen Tu

  • 1Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA. bhasin@bu.edu

Hormone Research in Paediatrics
|July 23, 2011
PubMed
Summary
This summary is machine-generated.

Anabolic therapies like androgens and myostatin inhibitors show promise for improving mobility in the elderly. Further consensus on clinical trial design is crucial for their development and regulatory approval.

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Area of Science:

  • Gerontology and Regenerative Medicine
  • Pharmacological Sciences
  • Clinical Trial Design

Background:

  • Global aging population presents challenges in mobility and daily living activities.
  • Growing interest in anabolic therapies to restore function in older adults.
  • Androgens and myostatin inhibitors are leading candidates for anabolic therapies.

Discussion:

  • Clinical development of anabolic therapies faces significant hurdles in trial design.
  • Need for standardized efficacy outcomes and functional difference metrics.
  • Collaboration between researchers, regulatory bodies, and funding agencies is essential.

Key Insights:

  • Anabolic therapies, including androgens and myostatin inhibitors, are under development to address age-related functional decline.
  • Current clinical trials are hampered by a lack of consensus on key design elements.
  • Defining clear indications, efficacy endpoints, and meaningful functional outcome differences is critical.

Outlook:

  • Achieving consensus on trial design will accelerate the approval of effective anabolic therapies.
  • Improved functional outcomes in the elderly can enhance quality of life and reduce healthcare burdens.
  • Future research should focus on optimizing therapeutic strategies and trial methodologies.