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Related Concept Videos

Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Chemotaxis in E. coli01:27

Chemotaxis in E. coli

Chemotaxis in Escherichia coli is a sensory-driven motility mechanism that enables bacteria to navigate chemical gradients, moving toward beneficial environments while avoiding harmful conditions. This process relies on a signal transduction system integrating external chemical cues with flagellar motor control.Chemoreceptors and Signal DetectionE. coli detects chemical gradients through methyl-accepting chemotaxis proteins (MCPs), which are membrane-bound chemoreceptors that sense attractants...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: May 30, 2026

Measurement of Cellular Chemotaxis with ECIS/Taxis
11:37

Measurement of Cellular Chemotaxis with ECIS/Taxis

Published on: April 1, 2012

Chemotaxis in cancer.

Evanthia T Roussos1, John S Condeelis, Antonia Patsialou

  • 1Department of Anatomy and Structural Biology, Program in Tumor Microenvironment and Metastasis, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA.

Nature Reviews. Cancer
|July 23, 2011
PubMed
Summary
This summary is machine-generated.

Chemotaxis guides tumor and stromal cells, driving cancer progression and metastasis. Understanding these cell movements offers new therapeutic targets and prognostic markers for cancer treatment.

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In vitro Cell Migration and Invasion Assays
09:55

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells
08:24

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells

Published on: September 14, 2016

Related Experiment Videos

Last Updated: May 30, 2026

Measurement of Cellular Chemotaxis with ECIS/Taxis
11:37

Measurement of Cellular Chemotaxis with ECIS/Taxis

Published on: April 1, 2012

In vitro Cell Migration and Invasion Assays
09:55

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells
08:24

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells

Published on: September 14, 2016

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Biology

Background:

  • Tumor cell and stromal cell chemotaxis are crucial for cancer progression and metastasis.
  • The tumor microenvironment is shaped by cell migration, influencing disease spread.

Purpose of the Study:

  • To review how chemotaxis directs tumor and stromal cell behaviors in vivo.
  • To explore molecular pathways regulating tumor cell chemotaxis.
  • To discuss chemotaxis's role in shaping the tumor microenvironment and metastatic spread.

Main Methods:

  • Literature review of studies on cell migration in cancer.
  • Analysis of molecular mechanisms underlying chemotaxis in tumor cells.
  • Examination of the clinical implications of chemotaxis in cancer progression.

Main Results:

  • Chemotaxis dictates distinct behaviors of tumor and stromal cells within the microenvironment.
  • Specific molecular pathways regulate the chemotactic responses of tumor cells.
  • Chemotaxis orchestrates the tumor microenvironment, significantly impacting metastatic potential.

Conclusions:

  • Chemotaxis is a fundamental process in cancer progression and metastasis.
  • Targeting chemotaxis presents a promising therapeutic strategy.
  • Chemotaxis serves as a valuable prognostic marker and treatment endpoint in oncology.