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Updated: May 30, 2026

Detection of Copy Number Alterations Using Single Cell Sequencing
Published on: February 17, 2017
Algebraic distribution of segmental duplication lengths in whole-genome sequence self-alignments
1Physics and Biology Unit, Okinawa Institute of Science and Technology, Kunigami, Okinawa, Japan.
Abstract:
Distributions of duplicated sequences from genome self-alignment are characterized, including forward and backward alignments in bacteria and eukaryotes. A Markovian process without auto-correlation should generate an exponential distribution expected from local effects of point mutation and selection on localised function; however, the observed distributions show substantial deviation from exponential form--they are roughly algebraic instead--suggesting a novel kind of long-distance correlation that must be non-local in origin.
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