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Updated: May 30, 2026
13:02
Sagittal Plane Kinematic Gait Analysis in C57BL/6 Mice Subjected to MOG35-55 Induced Experimental Autoimmune Encephalomyelitis
Published on: November 4, 2017
Gait abnormalities in multiple sclerosis: pathogenesis, evaluation, and advances in treatment
Michelle H Cameron1, Joanne M Wagner
1Portland VA Medical Center, OR, USA. cameromi@ohsu.edu
Current Neurology and Neuroscience Reports
|July 23, 2011
Summary
Multiple sclerosis (MS) causes significant gait dysfunction, impacting speed and stability. Treatments like exercise, medication, and assistive devices can improve walking ability in MS patients.
Area of Science:
- Neurology
- Rehabilitation Medicine
Background:
- Multiple sclerosis (MS) is a central nervous system demyelinating disease.
- Gait dysfunction is a common and debilitating symptom in MS patients.
Purpose of the Study:
- To review the characteristics of gait dysfunction in MS.
- To discuss methods for identifying and treating gait problems in MS.
Main Methods:
- Review of clinical measures, timed tests, and patient-reported outcomes.
- Analysis of observational, instrumented walkway, and 3D gait analysis techniques.
- Examination of various therapeutic interventions for MS gait dysfunction.
Main Results:
- MS gait is characterized by reduced speed, endurance, step length, cadence, and joint motion.
- Increased metabolic cost and variability of gait are also observed in MS.
- Multiple treatment strategies exist, targeting specific underlying causes of dysfunction.
Conclusions:
- Gait dysfunction in MS is multifaceted, affecting multiple parameters of walking.
- Accurate assessment is crucial for directing targeted and effective treatments.
- Interventions including exercise, medication, orthoses, and assistive devices can improve gait in MS.
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