Related Experiment Video
Updated: Jun 6, 2025
Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
Published on: January 29, 2016
Proximal Muscle Resistance Training to Improve Walking in People With Multiple Sclerosis: A Pilot Study
Mark M Mañago1, Jeri E Forster, Eliza Biondi
1Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO (M.M.M., J.E.F., E.B., M.S., C.L.C.); Department of Neurology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO (M.M.M.); Department of Research, VA Eastern Colorado Healthcare System, Aurora, CO (M.M.M.); Department of Veterans Affairs, VA Rocky Mountain Mental Illness Research Education and Clinical Center (MIRECC), Rocky Mountain Regional VA Medical Center, Aurora, CO (J.E.F); Department of Neurology, Oregon Health & Science University, Portland, OR (M.H.C); and Department of Veterans Affairs, VA Geriatric Research Education and Clinical Center (GRECC), Rocky Mountain Regional VA Medical Center, Aurora, CO (C.L.C.).
This pilot study found a proximal muscle resistance training program feasible for improving walking and strength in people with multiple sclerosis. Further research is warranted to confirm efficacy.
Area of Science:
- Neurology
- Physical Therapy
- Rehabilitation Medicine
Background:
- Multiple sclerosis (MS) is a chronic neurological disease impacting mobility.
- Walking impairment is a common and debilitating symptom in MS.
- Targeting proximal muscles may offer a novel approach to improve gait in MS patients.
Purpose of the Study:
- To assess the feasibility of a 10-week proximal muscle resistance training program for individuals with MS.
- To evaluate the program's impact on walking ability and muscle performance.
- To explore participant preferences for exercise delivery (in-person vs. virtual).
Main Methods:
- Recruited 28 individuals with MS (Expanded Disability Status Scale <6.0).
- Implemented a 10-week resistance training program focusing on hip abduction and trunk muscles.
- Measured walking tests, muscle strength/endurance, patient-reported outcomes, and daily step count pre- and post-intervention.
Main Results:
- The program was feasible, with high retention (92.8%) and adherence (86.5%).
- Significant improvements observed in 6-Minute Walk Test and Timed 25-Foot Walk Test.
- Muscle performance (hip abduction, trunk flexion strength/endurance) improved significantly.
Conclusions:
- Proximal muscle resistance training is a feasible intervention for individuals with MS.
- The program demonstrated positive effects on walking and muscle strength.
- Results support a future efficacy study to confirm these benefits.
