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The Stillbirth Collaborative Research Network neuropathologic examination protocol.

Halit Pinar1, Matthew A Koch, Hal Hawkins

  • 1Division of Perinatal Pathology, Women and Infants Hospital, Alpert School of Medicine, Brown University, Providence, Rhode Island 02905, USA. halit.pinar@gmail.com

American Journal of Perinatology
|July 23, 2011
PubMed
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The Stillbirth Collaborative Research Network (SCRN) established a standardized neuropathologic protocol for examining stillbirth (SB) central nervous system (CNS) cases. This largest prospective US study created a brain tissue repository for future stillbirth cause investigations.

Area of Science:

  • Neuropathology
  • Perinatal Medicine
  • Public Health

Background:

  • Stillbirth (SB) remains a significant concern, necessitating comprehensive research into its causes.
  • Standardized neuropathologic examination is crucial for accurate SB investigation.
  • The Stillbirth Collaborative Research Network (SCRN) was established to address these needs.

Purpose of the Study:

  • To describe the standardized neuropathologic procedure for central nervous system (CNS) examination in stillbirth (SB).
  • To establish a protocol for a large-scale, prospective, case-control study on SB causes.
  • To create a biological sample repository for future research.

Main Methods:

  • A standardized neuropathologic protocol was developed and implemented across all participating centers.

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  • Detailed data collection and standardized tissue sectioning were performed.
  • Fresh brain tissue was preserved for investigative purposes, creating a repository.

    • Main Results:

    • A total of 663 women with SB were enrolled in the case-control study.
    • Of these, 465 (70.1%) consented to CNS examination.
    • In 440 examined stillborn infants, brain tissue integrity varied, with 56.4% intact, 16.4% fragmented, and 27.3% liquefied.

    Conclusions:

    • The SCRN successfully implemented a standardized protocol for SB neuropathology, creating the largest prospective US study of its kind.
    • The established brain tissue repository and collected data will facilitate future investigations into stillbirth causes.
    • Standardized methods are essential for advancing stillbirth research and understanding its etiology.